Colorectal Oncogenomics Group

Discovering the causes of colorectal cancer, reducing its incidence, and improving patient outcomes.
Group Photo


Our research includes the identification and investigation of clinically and biologically relevant subtypes of colorectal cancer (CRC), including both familial and non-familial CRC, that can be identified through genetic, epigenetic, somatic and histopathological characterisation of CRC tumours and their pre-malignant lesions (polyps).

Key research areas
  • Identifying novel genetic risk factors for CRC.
  • Improving our understanding of major CRC-related diseases, such as Lynch Syndrome and Serrated Polyposis Syndrome
  • Identifying biomarkers of risk and poor prognosis in CRC.


Recent presentations

  • Identifying new colorectal cancer susceptibility variants: a case study in variant prioritisation and functional impact prediction, Intelligent Systems for Molecular Biology, Chicago, USA, July 6-10, 2018.
  • Update on the Genetics of Colonic Polyposis Study and Update on the ANGELS suspected Lynch syndrome study, New South Wales Family Cancer Clinics meeting, 3rd July 2018.
  • Genomic Approaches that Improve the Identification and Clinical Actionability of Hereditary Colorectal Cancer and Polyposis syndromes, Olivia Newton John Cancer Research Institute seminar series, 31 May 2018.

Recent activities

  • December 2017 - February 2018: James Chan undertakes student project investigating copy number variation in Familial Colorectal Cancer Type X.
  • 7 January, 2018: Dr Harindra Jayasekara awarded Victorian Cancer Agency Early Career Seed Grant for his project Can genomic profiling help predict who will get a second bowel tumour?
  • 28 November, 2017: Invited speaker at the Eastern Gynaecological and Obstetrical Society, Annual Partners Dinner, in Melbourne.
  • 13 - 14 September, 2017: Attended and presented at the Colon Cancer Family Registry Annual In-person Steering Committee Meeting, in Hawaii, USA.